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Oral Nicorandil for Prevention of Cardiac Death in Hemodialysis Patients without Obstructive Coronary Artery Disease: A Propensity-Matched Patient Analysis.
- Source :
-
Nephron Clinical Practice . Nov2011, Vol. 119 Issue 4, pc301-c309. 9p. 1 Diagram, 4 Charts, 1 Graph. - Publication Year :
- 2011
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Abstract
- Background/Aims: We examined the potential of oral administration of nicorandil for protecting against cardiac death in hemodialysis patients without obstructive coronary artery disease. Methods: This study was based on a cohort study of 155 hemodialysis patients with angiographic absence of obstructive coronary lesions, with analysis performed in 100 propensity-matched patients (54 men and 46 women, 64 ± 10 years), including 50 who received oral administration of nicorandil (15 mg/day, nicorandil group) and 50 who did not (control). The efficacy of nicorandil in preventing cardiac death was investigated. Results: Over a mean follow-up period of 5.3 ± 1.9 years, we observed 25 cardiac deaths among 100 propensity-matched patients, including 6 due to acute myocardial infarction, 11 due to heart failure, and 8 due to sudden cardiac death. The incidence of cardiac death was lower (p < 0.001) in the nicorandil group (4/50, 8%) than in the control (21/50, 42%). On multivariate Cox hazard analysis, cardiac death was inversely associated with oral nicorandil (hazard ratio, 0.123; p = 0.0002). On Kaplan-Meier analysis, cardiac death-free survival rates at 5 years were higher in the nicorandil group than in the control group (91.4 vs. 66.4%). Conclusion: Oral nicorandil may inhibit cardiac death of hemodialysis patients without obstructive coronary artery disease. Copyright © 2011 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 16602110
- Volume :
- 119
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Nephron Clinical Practice
- Publication Type :
- Academic Journal
- Accession number :
- 67653174
- Full Text :
- https://doi.org/10.1159/000329112