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Copper-mediated growth of amyloid β fibrils in the presence of oxidized and negatively charged liposomes
- Source :
-
Journal of Bioscience & Bioengineering . Dec2011, Vol. 112 Issue 6, p611-615. 5p. - Publication Year :
- 2011
-
Abstract
- ABSTRACT: Amyloid β protein (Aβ) from Alzheimer''s disease formed fibrillar aggregates and their morphology depended on oxidized and negatively charged liposomes. The morphology of fibrillar aggregates was affected by Cu2+, together with their growth kinetics. This is because Cu2+ inhibited the nucleation step in the formation of amyloid Aβ fibrillar aggregates by forming Aβ/Cu complex inactive to the growth of fibrillar aggregates. In addition, this is probably because Cu2+ affected the fibrillar aggregate formed on the surface of liposomes. These findings would give a better understanding of the formation mechanism of amyloid fibrils on biomembranes. [Copyright &y& Elsevier]
- Subjects :
- *COPPER
*AMYLOID
*LIPOSOMES
*ALZHEIMER'S disease
*BIOLOGICAL membranes
*GLYCOPROTEINS
Subjects
Details
- Language :
- English
- ISSN :
- 13891723
- Volume :
- 112
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Journal of Bioscience & Bioengineering
- Publication Type :
- Academic Journal
- Accession number :
- 69954997
- Full Text :
- https://doi.org/10.1016/j.jbiosc.2011.08.015