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Development of a solid-supported biotinylation reagent for efficient biotin labeling of SH groups on small molecules
- Source :
-
Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry . Feb2012, Vol. 53 Issue 5, p535-538. 4p. - Publication Year :
- 2012
-
Abstract
- Abstract: We report here the design and synthesis of a novel and selective SH-group biotinylating reagent, KSH-1 (1), for the biotinylation of small molecules using solid phase chemistry. The results demonstrate that 1 efficiently biotinylated a small molecule, captopril, and afforded the product in high yield and purity. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00404039
- Volume :
- 53
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 70035319
- Full Text :
- https://doi.org/10.1016/j.tetlet.2011.11.089