Clinical Analysis of Skin Lesions in 796 Chinese HIV-positive Patients.

Skin lesions are often associated with human immunode-ficiency virus (HIV) infection, reflecting the immunocom-promised status of the individual. We investigated the re-lationship between skin lesions and immune function in a retrospective study of 796 Chinese HIV patients with and without highly active antiretroviral therapy (HAART). Of the 651 patients who had not received HAART, we found that 531 (81.6%) had apparent skin lesions. The incidence of infectious skin diseases (fungi, viruses, bac-teria, spirochetes and parasites) and non-infectious skin diseases (excluding skin cancer) was 68.8% and 34.9%, respectively. Mean CD4+ T-cell counts and CD4 +/CD8+ ratios were lower in patients with skin lesions than in pa-tients without lesions (178 ± 96/µI vs. 306 ± 189/µl (p< 0.05) and 0.22 vs. 0.34 (p<0.01), respectively). Candidiasis (25.8%), eczema (19.2%), nodular prurigo (13.8%), der-matophyte infections (10.6%) and herpes zoster (9.4%) were most common in Chinese patients with HIV. Among the 145 patients who had started HAART, there was a significantly lower prevalence of skin diseases (29.0%), although drug eruptions (12.4%) were more commonly observed. These findings indicate that HAART often re-duces the incidence of infectious and non-infectious skin lesions in patients with HIV, but can itself be the cause of drug eruptions. [ABSTRACT FROM AUTHOR]