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Association of single nucleotide polymorphisms in IL-12 and IL-27 genes with colorectal cancer risk
- Source :
-
Clinical Biochemistry . Jan2012, Vol. 45 Issue 1/2, p54-59. 6p. - Publication Year :
- 2012
-
Abstract
- Abstract: Objectives: Interleukin-12 (IL-12) plays an important role in antitumor immunity. Interleukin-27 (IL-27) is a novel IL-12 family member. The present studies demonstrate that IL-27 mediates potent antitumor activity. However, No studies have examined the association of these polymorphism with colorectal cancer (CRC). Therefore, we investigated the relationship of IL-12 and IL-27 gene polymorphisms and CRC. Design and methods: We analyzed polymorphisms of IL-12 gene 16974 A/C and IL-27 gene −964 A/G, 2905 T/G, 4730 T/C in 410 patients with CRC and 450 controls, using PCR-RFLP method. Results: There were no significant differences in the genotype and allele frequencies of IL-12 and IL-27 gene polymorphisms between the group of patients with CRC and the controls. Furthermore, no association was found between IL-12 family gene polymorphisms and different clinical stages in patients with CRC. Conclusion: These findings suggest that IL-12 and IL-27 gene polymorphisms may not be involved in susceptibility to CRC. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00099120
- Volume :
- 45
- Issue :
- 1/2
- Database :
- Academic Search Index
- Journal :
- Clinical Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 70261803
- Full Text :
- https://doi.org/10.1016/j.clinbiochem.2011.10.004