Variant-type PML-RARα fusion transcript in acute promyelocytic leukemia: Use of a cryptic coding sequence from intron 2 of the RARα gene and identification of a new clinical subtype resistant to retinoic acid therapy.

Examines the physiologic actions of retinoic acids (RA) through RA receptors and retinoid X receptors. Assessment on chromosomal translocation in acute promyelocytic leukemia (APL); Types of PML-RARα transcripts; Importance of intron in molecular pathogenesis of APL.