Identification of Asm 19 as an Acyltransferase Attaching the Biologically Essential Ester Side Chain of Ansamitocins Using N-Desmethyl-4-,5-desepoxymaytansinol, Not Maytansinol, as Its Substrate.

Authors :: Moss, Steven J.
Linquan Bai
Toelzer, Sabine
Carroll, Brian J.
Mahmud, Taifo
Tin-Wein Yu
Floss, Heinz G.
Source :: Journal of the American Chemical Society. 6/12/2002, Vol. 124 Issue 23, p6544. 2p. 3 Diagrams.
Publication Year :: 2002
Abstract: Identifies the attachment of acyltransferase to the ansamitocins ester side chain. Hydrolysis of 3-esterified ansamitocins; Formation of amino-hydroxybenzoic acid; Acylation of the side chain.

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