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Baseline Plasma Levels of Interleukin-8 in Stage IV Non-Small-Cell Lung Cancer Patients: Relationship With Nutritional Status and Prognosis.
- Source :
-
Nutrition & Cancer . Jan2012, Vol. 64 Issue 1, p41-47. 7p. 4 Charts, 2 Graphs. - Publication Year :
- 2012
-
Abstract
- Interleukin (IL)-8 promotes cellular proliferation and angiogenesis in patients with non-small-cell lung cancer (NSCLC) and may be related to cachexia. Our aim was to investigate the relationship of IL-8 levels with nutritional status, and clinical outcome of patients with NSCLC. Patients with metastatic NSCLC referred for first-line therapy were eligible. Baseline IL-8 levels were measured in plasma. The Mini Nutritional Assessment (MNA) was used for the evaluation of the nutritional status, and patients were classified into 3 groups: A (score 24–30) “well nourished,” B (score 17–23.5) “risk of malnutrition,” and C (0–16.5) “malnourishment.” Response to first-line chemotherapy, time-to-tumor progression (TTP), and overall survival (OS) were also recorded. In total, 114 patients (101 males, 88.5%; mean age = 67.5 yr) were evaluated. Performance status was 0–1 in 62% of the patients. According to the MNA, the majority of patients (71%) was either at nutritional risk or malnourished. IL-8 levels were significantly different between MNA groups (P = 0.023) and correlated with TTP (P = 0.013) and OS (P = 0.001) in univariate analysis. Baseline IL-8 levels correlate with the nutritional status of patients with metastatic NSCLC, suggesting that this cytokine may be related with cachexia. [ABSTRACT FROM PUBLISHER]
- Subjects :
- *LUNG cancer diagnosis
*ACADEMIC medical centers
*BLOOD testing
*CANCER patients
*CHEMOKINES
*CONFIDENCE intervals
*STATISTICAL correlation
*DEMOGRAPHY
*DIET
*PATIENT aftercare
*INTERLEUKINS
*LUNG cancer
*EVALUATION of medical care
*MEDICAL referrals
*NUTRITION
*NUTRITIONAL requirements
*ONCOLOGY
*SURVIVAL analysis (Biometry)
*TUMOR classification
*DATA analysis
*PROPORTIONAL hazards models
*DATA analysis software
DEVELOPED countries
Subjects
Details
- Language :
- English
- ISSN :
- 01635581
- Volume :
- 64
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Nutrition & Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 70707723
- Full Text :
- https://doi.org/10.1080/01635581.2012.630157