Back to Search
Start Over
Colocalization of CA19-9 and KL-6 to epithelial cells in dilated bronchioles in a patient with idiopathic pulmonary fibrosis complicated by diffuse alveolar damage.
- Source :
-
Respirology . Sep2002, Vol. 7 Issue 3, p281-284. 4p. - Publication Year :
- 2002
-
Abstract
- A 73-year-old woman with idiopathic pulmonary fibrosis (IPF) had an elevated serum CA19-9 level, but not KL-6. Her condition worsened and she subsequently died and this was associated with a rise in the serum KL-6 level. At autopsy, the lung showed a honeycomb appearance macroscopically and, microscopically, hyaline membrane formation was seen. Immunohistochemical staining revealed partial colocalization of KL-6 and CA19-9 to dilated bronchiolar cells. These features suggest that the mechanisms that cause the synthesis and release of CA19-9 and KL-6 from damaged lung tissue in IPF are likely to differ from those in diffuse alveolar damage. In addition, serum KL-6 levels may reflect the severity of disease more sensitively than CA19-9 levels. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PULMONARY fibrosis
*EPITHELIAL cells
*BRONCHIOLES
Subjects
Details
- Language :
- English
- ISSN :
- 13237799
- Volume :
- 7
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Respirology
- Publication Type :
- Academic Journal
- Accession number :
- 7075098
- Full Text :
- https://doi.org/10.1046/j.1440-1843.2002.00391.x