Back to Search
Start Over
The gene INPPL1, encoding the lipid phosphatase SHIP2, is a candidate for type 2 diabetes in rat and man.
- Source :
-
Diabetes . Jul2002, Vol. 51 Issue 7, p2012-2017. 6p. 1 Diagram, 1 Chart, 2 Graphs. - Publication Year :
- 2002
-
Abstract
- Genetic susceptibility to type 2 diabetes involves many genes, most of which are still unknown. The lipid phosphatase SHIP2 is a potent negative regulator of insulin signaling and sensitivity in vivo and is thus a good candidate gene. Here we report the presence of SHIP2 gene mutations associated with type 2 diabetes in rats and humans. The R1142C mutation specifically identified in Goto-Kakizaki (GK) and spontaneously hypertensive rat strains disrupts a potential class II ligand for Src homology (SH)-3 domain and slightly impairs insulin signaling in cell culture. In humans, a deletion identified in the SHIP2 3' untranslated region (UTR) of type 2 diabetic subjects includes a motif implicated in the control of protein synthesis. In cell culture, the deletion results in reporter messenger RNA and protein overexpression. Finally, genotyping of a cohort of type 2 diabetic and control subjects showed a significant association between the deletion and type 2 diabetes. Altogether, our results show that mutations in the SHIP2 gene contribute to the genetic susceptibility to type 2 diabetes in rats and humans. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DISEASE susceptibility
*TYPE 2 diabetes
Subjects
Details
- Language :
- English
- ISSN :
- 00121797
- Volume :
- 51
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Diabetes
- Publication Type :
- Academic Journal
- Accession number :
- 7075672
- Full Text :
- https://doi.org/10.2337/diabetes.51.7.2012