Of Greek Heroes, Wiggling Worms, Mighty Mice, and Old Body Builders.

The editors discuss research into aging-related muscle mass and strength losses, arguing that more accurate animal models are needed to understand the processes controlling these declines in humans. Various issues related to clinical research are explored, including the correct muscle mass threshold for the diagnosis of sarcopenia, the assessment of physical performance, and the use of muscular strength loss as a predictor of mobility loss.