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N-acetylcysteine inhibits the induction of an antigen-specific antibody response down-regulating CD40 and CD27 co-stimulatory molecules.
- Source :
-
Clinical & Experimental Immunology . Aug2002, Vol. 129 Issue 2, p254-264. 11p. - Publication Year :
- 2002
-
Abstract
- SUMMARY We investigated the effect of N-acetylcysteine (NAC) on normal human B cell functions. We found that NAC significantly inhibited both the induction of the specific antibody response to the T-dependent antigen Candida albicans and T-dependent pokeweed mitogen (PWM)-induced polyclonal Ig production. NAC did not induce either cell death due to a non-specific toxicity or apoptosis. The NAC-induced inhibitory effect might be a functional consequence of: (i) a down-regulation of the expression on the B cell surface of CD40 and CD27 co-stimulatory molecules and (ii) a down-regulation of interleukin (IL-4) production. In contrast, NAC up-regulated interferon-γ (IFN-γ) production. NAC did not induce any effect on the T cell-independent B cell polyclonal activation system. These results indicate that NAC down-regulates T dependent B cell activation and leads to T helper cell type 1 (Th1) polarization. [ABSTRACT FROM AUTHOR]
- Subjects :
- *B cells
*ANTIGENS
*IMMUNE response
Subjects
Details
- Language :
- English
- ISSN :
- 00099104
- Volume :
- 129
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Clinical & Experimental Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 7094978
- Full Text :
- https://doi.org/10.1046/j.1365-2249.2002.01897.x