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Minimum Number of 2'-O-(2-Aminoethyl) Residues Required for Gene Knockout Activity by Triple Helix Forming Oligonucleotide.

Authors :
Puri, Nitin
Majumdar, Alokes
Cuenoud, Bernard
Natt, Francois
Martin, Pierre
Boyd, Andre
Miller, Paul S.
Seidman, Michael M.
Source :
Biochemistry. 6/18/2002, Vol. 41 Issue 24, p7716. 9p. 3 Diagrams, 11 Graphs.
Publication Year :
2002

Abstract

Investigates the bioactivity of the aminoethyl residues by triple helix forming oligonucleotide (TFO). Synthesis of TFO; Sensitivity of the pyrimidine motif triplexes to hydrogen-ion concentration; Formation of the triplexes by the TFO.

Details

Language :
English
ISSN :
00062960
Volume :
41
Issue :
24
Database :
Academic Search Index
Journal :
Biochemistry
Publication Type :
Academic Journal
Accession number :
7139898
Full Text :
https://doi.org/10.1021/bi025734y