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Recent advances in single-cell studies of gene regulation
- Source :
-
Current Opinion in Biotechnology . Feb2012, Vol. 23 Issue 1, p34-40. 7p. - Publication Year :
- 2012
-
Abstract
- A mechanistic understanding of gene regulatory network dynamics requires quantitative single-cell data of multiple network components in response to well-defined perturbations. Recent advances in the development of fluorescent biomarkers for proteins, detection of RNA and interactions, microfluidic technology, and high-resolution imaging have set the stage for a host of new studies that elucidate the important roles of stochasticity and cell–cell variability in response to external perturbations. In this review, we briefly describe methods for high-resolution visualization and the control of gene expression, along with application of these novel methods to recent studies involving gene networks. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09581669
- Volume :
- 23
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Current Opinion in Biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 71485871
- Full Text :
- https://doi.org/10.1016/j.copbio.2011.11.006