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Non-classical MHC-Ι genes in chronic hepatitis B and hepatocellular carcinoma.
- Source :
-
Immunogenetics . Mar2012, Vol. 64 Issue 3, p251-258. 8p. - Publication Year :
- 2012
-
Abstract
- The non-classical human leukocyte antigens (HLA)-E, HLA-G, and HLA-F have been shown to modulate immune responses. We examined whether non-classical HLA polymorphisms are associated with hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC). Fifteen Single-nucleotide polymorphisms (SNPs) in these non-classical class I alleles were investigated by ligase detection reaction. A fragment of 650 bp located in the 3' untranslated region of HLA-G was investigated. Four SNPs (rs17875380, rs41557518, rs114465251, and rs115492845) were associated with altered susceptibility to HBV or HCC, and HLA-F*01:04, HLA-G*01:05N, and HLA-E*01:01 were associated with hepatitis B or hepatitis B complicated with HCC. Six of 16 designated HLA-E, -G, and -F haplotypes were associated with risk of hepatitis B or HCC. Our study provides healthy reference and detailed analyses of non-classical HLA class Ι polymorphisms that provide insight into immune mechanisms involved in susceptibility to hepatitis B and HCC. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00937711
- Volume :
- 64
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Immunogenetics
- Publication Type :
- Academic Journal
- Accession number :
- 71509410
- Full Text :
- https://doi.org/10.1007/s00251-011-0580-2