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IgG Responses to Tissue-Associated Antigens as Biomarkers of Immunological Treatment Efficacy.
- Source :
-
Journal of Biomedicine & Biotechnology . 2011, p1-10. 10p. - Publication Year :
- 2011
-
Abstract
- We previously demonstrated that IgG responses to a panel of 126 prostate tissue-associated antigens are common in patients with prostate cancer. In the current report we questioned whether changes in IgG responses to this panel might be used as a measure of immune response, and potentially antigen spread, following prostate cancer-directed immune-active therapies. Sera were obtained from prostate cancer patients prior to and three months following treatment with androgen deprivation therapy (n = 34), a poxviral vaccine (n = 31), and a DNA vaccine (n = 21). Changes in IgG responses to individual antigens were identified by phage immunoblot. Patterns of IgG recognition following three months of treatment were evaluated using a machine-learned Bayesian Belief Network (ML-BBN).We found that different antigens were recognized following androgen deprivation compared with vaccine therapies. While the number of clinical responders was low in the vaccine-treated populations, we demonstrate that ML-BBN can be used to develop potentially predictive models. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 11107243
- Database :
- Academic Search Index
- Journal :
- Journal of Biomedicine & Biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 71520390
- Full Text :
- https://doi.org/10.1155/2011/454861