New Functionalizable AlkyltrichlorosilaneSurfaceModifiers for Biosensor and Biomedical Applications.

We report herein three unprecedented alkyltrichlorosilanesurfacemodifiers bearing pentafluorophenyl ester (PFP), benzothiosulfonate(BTS), or novel β-propiolactone (BPL) functionalizable terminalgroups. Evidence is provided that these molecules can be preparedin very high purity (as assessed by NMR) through a last syntheticstep of Pt-catalyzed alkene hydrosilylation then directly employed,without further purification, for the surface modification of quartzand medical grade stainless steel. Subsequent on-surface functionalizationswith amine and thiol model molecules demonstrate the potential ofthese molecular adlayers to be important platforms for future applicationsin the bioanalytical and biomedical fields. [ABSTRACT FROM AUTHOR]