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Antihypertensive effect of mulberry leaf aqueous extract containing γ-aminobutyric acid in spontaneously hypertensive rats

Antihypertensive effect of mulberry leaf aqueous extract containing γ-aminobutyric acid in spontaneously hypertensive rats

Authors :
Yang, Nae-Cherng
Jhou, Kun-Yan
Tseng, Chin-Yin
Source :
Food Chemistry. Jun2012, Vol. 132 Issue 4, p1796-1801. 6p.
Publication Year :
2012

Abstract

Abstract: We hypothesised that mulberry leaves (ML) exert their antihypertensive effect through γ-aminobutyric acid (GABA) and that the antihypertensive activity of ML extract would be comparable to GABA alone in spontaneously hypertensive rats (SHR). We found that single administration of a water extract from leaves of Morus alba L. (WEML) lowered systolic blood pressure (SBP) transiently in a dose-dependent manner. Interestingly, the SBP-lowering effect of WEML was significantly higher than after treatment with GABA alone. We further found that WEML strongly inhibited angiotensin I-converting enzyme (ACE) activity in vitro with an IC50 value of 29.8mg/ml. These results suggest that WEML has a transient antihypertensive effect in vivo that may involve a mechanism of ACE inhibition in addition to GABA. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
03088146
Volume :
132
Issue :
4
Database :
Academic Search Index
Journal :
Food Chemistry
Publication Type :
Academic Journal
Accession number :
71693952
Full Text :
https://doi.org/10.1016/j.foodchem.2011.11.143