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Antihypertensive effect of mulberry leaf aqueous extract containing γ-aminobutyric acid in spontaneously hypertensive rats
Antihypertensive effect of mulberry leaf aqueous extract containing γ-aminobutyric acid in spontaneously hypertensive rats
- Source :
-
Food Chemistry . Jun2012, Vol. 132 Issue 4, p1796-1801. 6p. - Publication Year :
- 2012
-
Abstract
- Abstract: We hypothesised that mulberry leaves (ML) exert their antihypertensive effect through γ-aminobutyric acid (GABA) and that the antihypertensive activity of ML extract would be comparable to GABA alone in spontaneously hypertensive rats (SHR). We found that single administration of a water extract from leaves of Morus alba L. (WEML) lowered systolic blood pressure (SBP) transiently in a dose-dependent manner. Interestingly, the SBP-lowering effect of WEML was significantly higher than after treatment with GABA alone. We further found that WEML strongly inhibited angiotensin I-converting enzyme (ACE) activity in vitro with an IC50 value of 29.8mg/ml. These results suggest that WEML has a transient antihypertensive effect in vivo that may involve a mechanism of ACE inhibition in addition to GABA. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 03088146
- Volume :
- 132
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Food Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 71693952
- Full Text :
- https://doi.org/10.1016/j.foodchem.2011.11.143