Back to Search
Start Over
Innate Response Activator B Cells Protect Against Microbial Sepsis.
- Source :
-
Science . 2/3/2012, Vol. 335 Issue 6068, p597-601. 5p. - Publication Year :
- 2012
-
Abstract
- Recognition and clearance of a bacterial infection are fundamental properties of innate immunity. Here, we describe an effector B cell population that protects against microbial sepsis. Innate response activator (IRA) B cells are phenotypically and functionally distinct, develop and diverge from B1a B cells, depend on pattern-recognition receptors, and produce granulocyte-macrophage colony-stimulating factor. Specific deletion of IRA B cell activity impairs bacterial clearance, elicits a cytokine storm, and precipitates septic shock. These observations enrich our understanding of innate immunity, position IRA B cells as gatekeepers of bacterial infection, and identify new treatment avenues for infectious diseases. [ABSTRACT FROM AUTHOR]
- Subjects :
- *B cells
*BACTERIAL diseases
*SEPSIS
*NATURAL immunity
*SEPTIC shock
*CYTOKINES
Subjects
Details
- Language :
- English
- ISSN :
- 00368075
- Volume :
- 335
- Issue :
- 6068
- Database :
- Academic Search Index
- Journal :
- Science
- Publication Type :
- Academic Journal
- Accession number :
- 71725375
- Full Text :
- https://doi.org/10.1126/science.1215173