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A Synthesis of 1,4-Disubstituted Imidazolidin-2-ones from Fused-Ring Aziridines.
- Source :
-
Synthesis . 2012, Vol. 2012 Issue 7, p551-560. 10p. - Publication Year :
- 2012
-
Abstract
- As part of an antibacterial drug discovery project, we were interested in preparing bioisosteric replacement analogues of 4,5-disubstituted oxazolidinones. One such isosteric replacement is the imidazolidinone ring system. Here, we report the development of a general synthesis of 1,4-disubstituted imidazolidinones that takes advantage of the base-catalyzed rearrangement of amino-methyl-substituted oxazolidinones. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PHARMACEUTICAL research
*ANTIBACTERIAL agents
*CATALYSIS
*AMINO acids
*IMIDAZOLES
Subjects
Details
- Language :
- English
- ISSN :
- 00397881
- Volume :
- 2012
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Synthesis
- Publication Type :
- Academic Journal
- Accession number :
- 71920839
- Full Text :
- https://doi.org/10.1055/s-0031-1289684