Back to Search
Start Over
Total Synthesis and Antidepressant Activities of Laetispicine and Its Derivatives.
- Source :
-
Molecules . Feb2012, Vol. 17 Issue 2, p1425-1436. 47p. 7 Diagrams, 1 Graph. - Publication Year :
- 2012
-
Abstract
- The first total synthesis of laetispicine (1a), an amide alkaloid isolated from the stems of Piper laetispicum C.DC (Piperaceae), and the synthesis of some of its derivatives were described. Based on the evaluation of antidepressant activities in the forced swimming test, compounds 1h and 1i were identified as potent and safe antidepressant lead compounds. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ANTIDEPRESSANTS
*LEAD compounds
*PIPERACEAE
*DRUG derivatives
*NATURAL products
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 17
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Molecules
- Publication Type :
- Academic Journal
- Accession number :
- 72015109
- Full Text :
- https://doi.org/10.3390/molecules17021425