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Redundant Catecholamine Signaling Consolidates Fear Memory via Phospholipase C.
- Source :
-
Journal of Neuroscience . 2/8/2012, Vol. 32 Issue 6, p1932-1941. 10p. - Publication Year :
- 2012
-
Abstract
- Memories for emotionally arousing experiences are typically vivid and persistent. The recurrent, intrusive memories of traumatic events in post-traumatic stress disorder (PTSD) are an extreme example. Stress-responsive neurotransmitters released during emotional arousal are proposed to enhance the consolidation of fear memory. These transmitters may include norepinephrine and epinephrine (NE/E) because stimulating &bgr;-adrenergic receptors shortly after training can enhance memory consolidation. However, mice lacking NE/E acquire and consolidate fear memory normally. Here, we show by using pharmacologic and genetic manipulations in mice and rats that NE/E are not essential for classical fear memory consolidation because signaling by the &bgr;2-adrenergic receptor is redundant with signaling by dopamine at the D5-dopaminergic receptor. The intracellular signaling that is stimulated by these receptors to promote consolidation uses distinct G proteins to redundantly activate phospholipase C. The results support recent evidence indicating that blocking-&bgr;adrenergic receptors alone shortly after trauma may not be sufficient to prevent PTSD. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02706474
- Volume :
- 32
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Journal of Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 72165691
- Full Text :
- https://doi.org/10.1523/JNEUROSCI.5231-11.2012