Protección Cerebral ante el Daño Neuronal.

Brain protection includes many therapeutic measures to put in practice in order to maintain neuronal integrity and its physiological interactions. The objective of these strategies is to reduce ischemic neuronal loss that follows a brain lesion. Some preventive procedures can be set in practice to control spread of the ischemic-hypoxic event to wider brain areas; as is the case with nimodipine administration to reduce the secondary spasm that happens after aneurismatic rupture and hypoxia. The therapeutic measures have the intention of minimizing the initial damage. Brain injury may appear as the result of the primary event that can be traumatic, hypoxic or ischemic. When this event occur, pharmacological and non-pharmacological treatment can be installed for controlling several physiological parameters. Intensive therapy can include a combination of the following procedures and pharmacological agents: a) body hypothermia, hemodilution, induced hypertension b) general anesthetics administration c) glucecorticoids, as methylprednisolone d) calcium antagonistas e) magnesium sulphate f) statins g) glutamate antagonists h) Buffer THAM I) aminosteroids or lazaroid compounds j) osmotic diuretics k) hemorheological agents as piracetam and I) neurosurgical approach. [ABSTRACT FROM AUTHOR]