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Immunologic Correlates of the Abscopal Effect in a Patient with Melanoma.
- Source :
-
New England Journal of Medicine . 3/8/2012, Vol. 366 Issue 10, p925-931. 7p. 3 Diagrams. - Publication Year :
- 2012
-
Abstract
- : The abscopal effect is a phenomenon in which local radiotherapy is associated with the regression of metastatic cancer at a distance from the irradiated site. The abscopal effect may be mediated by activation of the immune system. Ipilimumab is a monoclonal antibody that inhibits an immunologic checkpoint on T cells, cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4). We report a case of the abscopal effect in a patient with melanoma treated with ipilimumab and radiotherapy. Temporal associations were noted: tumor shrinkage with antibody responses to the cancer–testis antigen NY-ESO-1, changes in peripheral-blood immune cells, and increases in antibody responses to other antigens after radiotherapy. (Funded by the National Institutes of Health and others.) [ABSTRACT FROM PUBLISHER]
- Subjects :
- *MELANOMA
*IMMUNOLOGY
*RADIOTHERAPY
*METASTASIS
*IPILIMUMAB
Subjects
Details
- Language :
- English
- ISSN :
- 00284793
- Volume :
- 366
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- New England Journal of Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 72697245
- Full Text :
- https://doi.org/10.1056/NEJMoa1112824