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Rational polytherapy with lacosamide in clinical practice: Results of a Spanish cohort analysis RELACOVA
- Source :
-
Epilepsy & Behavior . Mar2012, Vol. 23 Issue 3, p298-304. 7p. - Publication Year :
- 2012
-
Abstract
- Abstract: There has been little long-term success with polytherapy for patients with refractory partial-onset epilepsy. The rational combination of antiepileptic drugs based on their mechanism of action may help improve treatment efficacy and tolerability. Lacosamide, a novel sodium channel blocker (SCB), was investigated in 158 patients with partial-onset epilepsy in the prospective, multicenter, observational, RELACOVA cohort study conducted in Spain. After 12months'' treatment with lacosamide, 47% of patients were responders (≥50% reduction in seizure frequency) and 24% were seizure free. Lacosamide was well tolerated; dizziness was the most frequent adverse event. Efficacy was better (responder rate, 65% vs 38%; seizure free rate, 35% vs 17%) and there was a lower adverse event rate (33% vs 58%) in patients receiving non-SCBs (n=49) versus those receiving SCBs (n=104) as concomitant therapy at baseline. Further investigation of lacosamide combination therapy is warranted. [Copyright &y& Elsevier]
- Subjects :
- *VIMPAT
*EPILEPSY
*ANTICONVULSANTS
*DRUG efficacy
*DRUG tolerance
*COHORT analysis
Subjects
Details
- Language :
- English
- ISSN :
- 15255050
- Volume :
- 23
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Epilepsy & Behavior
- Publication Type :
- Academic Journal
- Accession number :
- 73762631
- Full Text :
- https://doi.org/10.1016/j.yebeh.2011.11.026