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In vitro antimalarial activity and molecular docking analysis of 4-aminoquinoline-clubbed 1,3,5-triazine derivatives.
- Source :
-
Letters in Applied Microbiology . May2012, Vol. 54 Issue 5, p483-486. 4p. 1 Chart. - Publication Year :
- 2012
-
Abstract
- Aims: Present report describes the in vitro antimalarial activity and docking analysis of seven 4-aminoquinoline-clubbed 1,3,5-triazine derivatives on pf-DHFR-TS. Methods and Results: The antimalarial activity was evaluated in vitro against chloroquine-sensitive 3D7 strain of Plasmodium falciparum. Compounds were docked onto the active site of pf-DHFR-TS using docking server to explicate necessary structural requirements for antimalarial activity. Conclusion: Title molecules demonstrated considerable bioactivity against the malaria parasite. Docking analysis revealed deep engulfment of the molecules into the inner groove of pf-DHFR-TS active site by making stable ligand-receptor posses. Hydrophobic interaction was identified as the only major interacting force playing a role between ligand-receptor interaction and minor with hydrogen bonds. Significance and Impact of the study: The study provided the novel insight into the necessary structural requirement for rationale-based antimalarial drug discovery. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02668254
- Volume :
- 54
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Letters in Applied Microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 74132573
- Full Text :
- https://doi.org/10.1111/j.1472-765X.2012.03234.x