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EFFECTS OF CHLORELLA VULGARIS EXTRACT ON CYTOKINES PRODUCTION IN LISTERIA MONOCYTOGENES INFECTED MICE.
- Source :
-
Immunopharmacology & Immunotoxicology . Aug2002, Vol. 24 Issue 3, p483-496. 14p. - Publication Year :
- 2002
-
Abstract
- In this study, we have investigated the effects of the unicellular-green-algae Chlorella vulgaris on the production of INF-γ, IL-2, IL-4 and IL-10 in normal and Listeria monocytogenes infected mice. Our results demonstrated that in normal/non infected mice, CVE administration produced no effects in the levels of all cytokines studied. However, Listeria monocytogenes infection enhanced the production of INF-γ and IL-2 at 48 and 72 h after the bacteria inoculation. Interestingly, the treatment with five consecutive doses of 50 mg/Kg/day of Chlorella vulgaris given previously to infection, led to further increases in INF-γ and IL-2 levels at 48 and 72 h in relation to the presence of infection alone. No changes in IL-4 and IL-10 production were observed in Listeria monocytogenes and CVE treated/infected mice. These results are in accordance with the literature, which shows that CVE is a biological response modifier that enhances resistance to Listeria monocytogenes through augmentation of IL-2 and IFN-γ. [ABSTRACT FROM AUTHOR]
- Subjects :
- *GREEN algae
*INTERFERONS
*INTERLEUKIN-2
*INTERLEUKIN-4
*INTERLEUKIN-10
Subjects
Details
- Language :
- English
- ISSN :
- 08923973
- Volume :
- 24
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Immunopharmacology & Immunotoxicology
- Publication Type :
- Academic Journal
- Accession number :
- 7415678
- Full Text :
- https://doi.org/10.1081/IPH-120014731