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Adenovirus-Vectored Drug-Vaccine Duo as a Rapid- Response Tool for Conferring Seamless Protection against Influenza.
- Source :
-
PLoS ONE . 2011, Vol. 6 Issue 7, p1-8. 8p. - Publication Year :
- 2011
-
Abstract
- Few other diseases exert such a huge toll of suffering as influenza. We report here that intranasal (i.n.) administration of E1/ E3-defective (DE1E3) adenovirus serotype 5 (Ad5) particles rapidly induced an anti-influenza state as a means of prophylactic therapy which persisted for several weeks in mice. By encoding an influenza virus (IFV) hemagglutinin (HA) HA1 domain, an Ad5-HA1 vector conferred rapid protection as a prophylactic drug followed by elicitation of sustained protective immunity as a vaccine for inducing seamless protection against influenza as a drug-vaccine duo (DVD) in a single package. Since Ad5 particles induce a complex web of host responses, which could arrest influenza by activating a specific arm of innate immunity to impede IFV growth in the airway, it is conceivable that this multi-pronged influenza DVD may escape the fate of drug resistance that impairs the current influenza drugs. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 6
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- PLoS ONE
- Publication Type :
- Academic Journal
- Accession number :
- 74549055
- Full Text :
- https://doi.org/10.1371/journal.pone.0022605