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Highly efficient synthesis and antitumor activity of monosaccharide saponins mimicking components of Chinese folk medicine Cordyceps sinensis.

Authors :
Zhu, Zhen-Yuan
Yao, Qiang
Liu, Yang
Si, Chuan-Ling
Chen, Jing
Liu, Nian
Lian, Hong-Yu
Ding, Li-Na
Zhang, Yong-Min
Source :
Journal of Asian Natural Products Research. May2012, Vol. 14 Issue 5, p429-435. 7p.
Publication Year :
2012

Abstract

Ergosterol 3-O-β-d-glucopyranoside (1a) and ergosterol 3-O-β-d-galactopyranoside (1b) were highly efficiently synthesized and evaluated for their inhibitory activities against two tumor cell lines. The structures of these compounds were extensively confirmed by 1H, 13C NMR, IR, and HRMS. Compounds 1a and 1b exhibited interesting cytotoxic profiles. The antitumor activity of compound 1a was higher than that of 1b. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10286020
Volume :
14
Issue :
5
Database :
Academic Search Index
Journal :
Journal of Asian Natural Products Research
Publication Type :
Academic Journal
Accession number :
74550007
Full Text :
https://doi.org/10.1080/10286020.2012.670220