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Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis.
- Source :
-
Nature Genetics . May2012, Vol. 44 Issue 5, p522-525. 4p. - Publication Year :
- 2012
-
Abstract
- To find new candidate loci predisposing individuals to Kawasaki disease, an acute vasculitis that affects children, we conducted a genome-wide association study in 622 individuals with Kawasaki disease (cases) and 1,107 controls in a Han Chinese population residing in Taiwan, with replication in an independent Han Chinese sample of 261 cases and 550 controls. We report two new loci, one at BLK (encoding B-lymphoid tyrosine kinase) and one at CD40, that are associated with Kawasaki disease at genome-wide significance (P < 5 × 10?8). Our findings may lead to a better understanding of the role of immune activation and inflammation in Kawasaki disease pathogenesis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10614036
- Volume :
- 44
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Nature Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 74604518
- Full Text :
- https://doi.org/10.1038/ng.2227