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Clinical Utility of Serum Interleukin-8 and Interferon-Alpha in Thyroid Diseases.
- Source :
-
Journal of Thyroid Research . 2011, p1-10. 10p. 4 Charts, 4 Graphs. - Publication Year :
- 2011
-
Abstract
- Serum interleukin-8 (IL-8) and interferon-alpha (IFN-α) levels have been estimated from a total of 88 individuals of which 19 were disease-free healthy individuals, and 69 were patients with thyroid diseases: goitre (N = 21), autoimmune diseases (N = 16), and carcinomas (N = 32). Both IL-8 and IFN-α were significantly higher in all the patients as compared to healthy individuals. Serum IL-8 levels showed significant positive correlation with disease stage in thyroid cancer patients. Higher serum IL-8 levels were associated with advanced disease stage while no significant correlation was observed between serum IFN-α levels and any of the clinicopathological parameters. IL-8 and IFN-α significantly correlated with each other in anaplastic carcinoma patients. Finally concluding, monitoring the serum IL-8 and IFN-α levels can help differentiate patients with thyroid diseases from healthy individuals, and IL-8 seems to have a role in the pathogenesis of thyroid diseases and may represent a target for innovative diagnostic and therapeutic strategies. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20908067
- Database :
- Academic Search Index
- Journal :
- Journal of Thyroid Research
- Publication Type :
- Academic Journal
- Accession number :
- 74619726
- Full Text :
- https://doi.org/10.4061/2011/270149