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A novel locus for body mass index on 5p15.2: A meta-analysis of two genome-wide association studies
- Source :
-
Gene . May2012, Vol. 500 Issue 1, p80-84. 5p. - Publication Year :
- 2012
-
Abstract
- Abstract: Objective: Genetic factors play an important role in modulating the vulnerability to body mass index (BMI). The purpose of this study is to identify novel genetic variants for BMI using genome-wide association (GWA) meta-analysis. Methods: PLINK software was used to perform meta-analysis of two GWA studies (the FUSION and Marshfield samples) of 5218 Caucasian individuals with BMI. A replication study was conducted using the SAGE sample with 762 individuals. Results: Through meta-analysis we identified 33 SNPs associated with BMI with p<10−4. The most significant association was observed with rs2967951 (p=1.19×10−6) at 5p15.2 within ROPN1L gene. Two additional SNPs within ROPN1L and 5 SNPs within MARCH6 (the top SNP was rs2607292 with 4.27×10−6) further supported the association with BMI on 5p15.2 (p<1.8×10−5). Conditional analysis on 5p15.2 could not distinguish the effects of ROPN1L and MARCH6. Several SNPs within MARCH6 and ROPN1L were replicated in the SAGE sample (p<0.05). Conclusion: We identified a novel locus for BMI. These findings offer the potential for new insights into the pathogenesis of BMI and obesity and will serve as a resource for replication in other populations to elucidate the potential role of these genetic variants in BMI and obesity. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 03781119
- Volume :
- 500
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Gene
- Publication Type :
- Academic Journal
- Accession number :
- 74662522
- Full Text :
- https://doi.org/10.1016/j.gene.2012.03.046