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Virus-like particles and α-galactosylceramide form a self-adjuvanting composite particle that elicits anti-tumor responses
- Source :
-
Journal of Controlled Release . May2012, Vol. 159 Issue 3, p338-345. 8p. - Publication Year :
- 2012
-
Abstract
- Abstract: Virus-like particles (VLP) are effective vehicles for delivery of heterologous antigen to antigen-presenting cells. However VLP alone are insufficiently stimulatory to generate the signals required to facilitate effective priming of naïve T cells. We show that the VLP derived from rabbit hemorrhagic disease virus can bind the galactose-containing adjuvant α-galactosylceramide to form a composite particle for co-delivery of antigen and adjuvant to the same antigen-presenting cell. Vaccination with VLP and α-galactosylceramide activated splenic iNKT cells to produce IFN-γ and IL-4, led to the generation of antigen-specific T cells that protected prophylactically against subcutaneous tumor challenge, and was more effective at generating anti-tumor immune responses than either component individually. These data demonstrate a novel method for immunopotentiating VLP to increase their efficacy in the generation of anti-tumor responses via the innate ligand recognition properties of calicivirus-derived nanoparticles. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 01683659
- Volume :
- 159
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of Controlled Release
- Publication Type :
- Academic Journal
- Accession number :
- 74988847
- Full Text :
- https://doi.org/10.1016/j.jconrel.2012.02.015