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Leiomyosarcoma Showing Partial Synthetic-Phase Differentiation.
- Source :
-
Ultrastructural Pathology . Sep2002, Vol. 26 Issue 5, p335-340. 6p. - Publication Year :
- 2002
-
Abstract
- An unusual leiomyosarcoma in the thigh of a 53-year-old woman is described. Tumor cells were spindled and positive for muscle immuno-markers. Some cells exhibited typical smooth-muscle ultrastructure - abundant myofilaments, focal densities, attachment plaques, plasmalemmal caveolae, and lamina. Others had fewer myofilaments and prominent rough endoplasmic reticulum. These features indicated a variable phenotype that included synthetic-phase (matrigenic) differentiation. Synthetic-phase cells were distinguished from myofibroblasts by typical smooth-muscle surface features in the absence of fibronexus junctions. In a subset of cells myofilaments were absent, but structures resembling solitary focal densities were identified. These are discussed as possible indicators of a primitive level of smooth-muscle differentiation. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SMOOTH muscle tumors
*CELL differentiation
Subjects
Details
- Language :
- English
- ISSN :
- 01913123
- Volume :
- 26
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Ultrastructural Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 7516067
- Full Text :
- https://doi.org/10.1080/01913120290104629