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Partial Molar Isentropic Compressions of Some Tetra- and Pentapeptides in Aqueous Solution: Implications for Group Additivity Schemes for Unfolded Proteins.
- Source :
-
Journal of Solution Chemistry . May2012, Vol. 41 Issue 4, p690-701. 12p. - Publication Year :
- 2012
-
Abstract
- Sound speeds have been measured for aqueous solutions of five tetrapeptides and five pentapeptides at T=298.15 K. The partial molar isentropic compressions at infinite dilution, $K_{S,2}^{\circ}$, were derived for the peptides using conventional methods. The results were compared with those calculated using group additivity methods, with the amino acid side-chain contributions derived using $K_{S,2}^{\circ}$ data reported previously for some tripeptides of sequence gly-X-gly, where X represents an amino acid, and also for some N-acetyl amino acid amides. The tripeptides are the preferred model compounds for the estimation of the side-chain contributions to $K_{S,2}^{\circ}$ of a polypeptide. Our study also confirms that simple group additivity schemes are not feasible for the estimation of $K_{S,2}^{\circ}$ values for polypeptides and unfolded proteins. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SPEED of sound
*AQUEOUS solutions
*PEPTIDES
*AMINO acids
*POLYPEPTIDES
Subjects
Details
- Language :
- English
- ISSN :
- 00959782
- Volume :
- 41
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Journal of Solution Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 75231855
- Full Text :
- https://doi.org/10.1007/s10953-012-9818-3