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Detection and clinical relevance of donor specific HLA antibodies: a matter of debate.
- Source :
-
Transplant International . Jun2012, Vol. 25 Issue 6, p604-610. 7p. - Publication Year :
- 2012
-
Abstract
- The introduction of new sensitive assays for the detection of HLA antibodies on basis of their binding to isolated HLA molecules has got an enormous impact on the decision-making process with respect to donor selection for sensitized patients. In the past, when only complement-dependent cytotoxicity was used as a tool to define HLA alloantibodies, the presence of donor specific antibodies (DSA) before transplantation was considered a contraindication for renal transplantation with that donor. The interpretation of the current DSA results is far more difficult and leads to a lot of discussions and controversy. The problems associated with the use of solid phase assays for clinical decision making and possible solutions are discussed. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09340874
- Volume :
- 25
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Transplant International
- Publication Type :
- Academic Journal
- Accession number :
- 75233042
- Full Text :
- https://doi.org/10.1111/j.1432-2277.2012.01491.x