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The dopamine b-hydroxylase 19 bp insertion/deletion polymorphism was associated with first-episode but not medicated chronic schizophrenia
- Source :
-
Journal of Psychiatric Research . Jun2012, Vol. 46 Issue 6, p733-737. 5p. - Publication Year :
- 2012
-
Abstract
- Abstract: Background: Numerous studies report dysfunctional dopaminergic and noradrenergic neurotransmission in the pathogenesis of schizophrenia. Dopamine beta-hydroxylase (DBH) is an intracellular enzyme catalyzing the conversion of dopamine to noradrenaline. Functional polymorphisms have been reported in the promoter region of DBH gene, including a 19 bp insertion/deletion polymorphism. The purpose of this study was to investigate whether there was an association between the functional polymorphism (DBH5′-Ins/Del) and schizophrenia in a Han Chinese population. Methods: This polymorphism was genotyped in 221 first-episode schizophrenics, 360 chronic schizophrenics and 318 healthy controls using a case-control design. We assessed their psychopathology using the Positive and Negative Syndrome Scale (PANSS). Results: We showed that the DBH5′-Ins/Del deletion (Del) allelic and genotypic frequencies were significantly lower in controls than first-episode of schizophrenics (FES) (both p < 0.001), but controls were not different from chronic schizophrenics. Furthermore, the PANSS positive symptom and total scores were significantly higher in FES with the Del/Del genotype than those with Ins/Del and Ins/Ins genotypes (all p < 0.05). Conclusions: The DBH5′-Ins/Del polymorphism may play a role in susceptibility to the positive symptoms of FES and to these FES not progressing on to chronic schizophrenia. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00223956
- Volume :
- 46
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Journal of Psychiatric Research
- Publication Type :
- Academic Journal
- Accession number :
- 75356133
- Full Text :
- https://doi.org/10.1016/j.jpsychires.2012.02.016