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A Genetic Variant in the Promoter Region of Toll-Like Receptor 9 and Cervical Cancer Susceptibility.
- Source :
-
DNA & Cell Biology . May2012, Vol. 31 Issue 5, p766-771. 6p. 4 Charts. - Publication Year :
- 2012
-
Abstract
- The Toll-like receptors (TLRs) are important for the innate immune system by recognizing pathogen-associated molecular patterns expressed in infectious agents. E6 and E7 protein from HPV16 suppress the host immune response by regulating the TLR9 transcript. Therefore, we hypothesized that a single nucleotide polymorphism in TLR9 may contribute to cervical cancer. We genotyped TLR9 -1486T/C (rs187084) in a case-control study of 712 cervical cancer cases and 717 cancer-free controls in Chinese women. Logistic regression analyses showed that the rs187084 heterozygote TC was associated with a significantly increased risk of cervical cancer (adjusted OR=1.28, 95% CI=1.01-1.62), compared with the TT genotype. Although the variant homozygote was associated with a nonsignificantly increased cervical cancer risk, the TC/CC genotypes contributed to the risk of cervical cancer in the dominant genetic model (adjusted OR=1.24, 95% CI=1.01-1.53). The findings indicate that TLR9 -1486T/C (rs187084) may contribute to cervical cancer carcinogenesis. [ABSTRACT FROM AUTHOR]
- Subjects :
- *TOLL-like receptors
*CERVICAL cancer
*IMMUNE response
*CANCER in women
Subjects
Details
- Language :
- English
- ISSN :
- 10445498
- Volume :
- 31
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- DNA & Cell Biology
- Publication Type :
- Academic Journal
- Accession number :
- 75367940
- Full Text :
- https://doi.org/10.1089/dna.2011.1427