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Cyclooxygenase-2 expression in the normal human eye and its expression pattern in selected eye tumours.
- Source :
-
Acta Ophthalmologica (1755375X) . Nov2011, Vol. 89 Issue 7, p681-685. 5p. - Publication Year :
- 2011
-
Abstract
- . Purpose: Cyclooxygenase-2 (COX-2) is an enzyme involved in neoplastic processes. The purpose of the present study is to investigate COX-2 expression in the normal human eye and the expression pattern in selected eye tumours involving COX-2 expressing cells. Methods: Immunohistochemical staining using antibodies against COX-2 was performed on paraffin sections of normal human eyes and selected eye tumours arising from cells expressing COX-2. Results: Cyclooxygenase-2 expression was found in various structures of the normal eye. Abundant expression was seen in the cornea, iris, ciliary body and retina. The COX-2 expression was less in tumours deriving from the ciliary epithelium and also in retinoblastoma. Conclusion: Cyclooxygenase-2 is constitutively expressed in normal human eyes. The expression of COX-2 is much lower in selected eye tumours involving COX-2 expressing cells. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1755375X
- Volume :
- 89
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Acta Ophthalmologica (1755375X)
- Publication Type :
- Academic Journal
- Accession number :
- 75409717
- Full Text :
- https://doi.org/10.1111/j.1755-3768.2009.01765.x