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A circuit design of a low-cost, portable and programmable electroporation device for biomedical applications
- Source :
-
Sensors & Actuators B: Chemical . May2012, Vol. 166-167, p292-300. 9p. - Publication Year :
- 2012
-
Abstract
- Abstract: Electroporation for transdermal drug delivery or for non-invasive monitoring of patients could allow a new generation of medical devices to be developed for low-cost healthcare. The existing electroporation systems today are bulky, expensive or not fully programmable. Therefore, a compact, low-cost and programmable device was developed and evaluated. A circuit is described herein which provides a variety of adjustable high-voltage (2–300V) electric waveforms (pulsed and pulsed-biphasic) for electroporation. Evaluation showed that this device provides for precise regulation of the magnitude and waveform of a high-voltage over a wide range of impedance, important for in vivo/human use. Also, the device was evaluated in vitro to be capable of enhancing transdermal extraction of metabolites, like uric acid, for non-invasive monitoring and transdermal delivery of medications, like insulin, for non-invasive drug delivery. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 09254005
- Volume :
- 166-167
- Database :
- Academic Search Index
- Journal :
- Sensors & Actuators B: Chemical
- Publication Type :
- Academic Journal
- Accession number :
- 75450261
- Full Text :
- https://doi.org/10.1016/j.snb.2012.02.065