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Human adenovirus Ad-36 promotes weight gain in male rhesus and marmoset monkeys.
- Source :
-
Journal of Nutrition . Oct2002, Vol. 132 Issue 10, p3155-3160. 6p. 1 Black and White Photograph, 2 Charts, 4 Graphs. - Publication Year :
- 2002
-
Abstract
- Although obesity has multiple etiologies, an overlooked possibility is an infectious origin. We previously identified two viruses, SMAM-1, an avian adenovirus (Ad), and Ad-36, a human adenovirus, that produce a syndrome of visceral obesity, with paradoxically decreased serum cholesterol and triglycerides in chickens and mice. In the two studies presented in this paper, we used nonhuman primates to investigate the adiposity-promoting potential of Ad-36. In study 1, we observed spontaneously occurring Ad-36 antibodies in 15 male rhesus monkeys, and a significant longitudinal association of positive antibody status with weight gain and plasma cholesterol lowering during the 18 mo after viral antibody appearance. In study 2, which was a randomized controlled experiment, three male marmosets inoculated with Ad-36 had a threefold body weight gain, a greater fat gain and lower serum cholesterol relative to baseline (P <0.05) than three uninfected controls at 28 wk postinoculation. These studies illustrate that the adiposity-promoting effect of Ad-36 occurs in two nonhuman primate species and demonstrates the usefulness of nonhuman primates for further evaluation of Ad-36-induced adiposity. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ADENOVIRUSES
*WEIGHT gain
*LABORATORY monkeys
*ADIPOSE tissues
*ANIMAL experimentation
*BIOLOGICAL models
*CHOLESTEROL
*COMPARATIVE studies
*RESEARCH methodology
*MEDICAL cooperation
*OBESITY
*PRIMATES
*RESEARCH
*STATISTICAL sampling
*VIRAL antibodies
*VIRUSES
*EVALUATION research
*DNA virus diseases
*DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 00223166
- Volume :
- 132
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Journal of Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 7571288
- Full Text :
- https://doi.org/10.1093/jn/131.10.3155