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Synthesis and structure–activity relationship of aminopyridines with substituted benzoxazoles as c-Met kinase inhibitors
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Jun2012, Vol. 22 Issue 12, p4044-4048. 5p. - Publication Year :
- 2012
-
Abstract
- Abstract: A series of hydroxybenzoxazole derivatives was synthesized, and their c-Met kinase inhibitory activity was evaluated. Described herein is a potent c-Met inhibitor by structural modification of the parent benzoxazole scaffold, with particular focus on the hydroxyl substituent of the benzoxazole moiety. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 22
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 76186754
- Full Text :
- https://doi.org/10.1016/j.bmcl.2012.04.083