Simplification of biochemical models: a general approach based on the analysis of the impact of individual species and reactions on the systems dynamics.

The article discusses efforts of biology researchers who tend to build ever increasing computational models in the wake of the complex mechanisms underlying biochemical processes systems. It informs that researchers have developed a strategy based on Computational Singular Perturbation (CSP) method which can be used to perform a "biochemically-driven" model reduction of even large and complex kinetic ODE systems. It informs on usefulness of method for model simplification purposes.