l-Proline-catalyzed diastereoselective synthesis of cis-isoquinolonic acids and evaluation of their neuroprotective effects

Authors :: Karimi, Ali Reza
Momeni, Hamid Reza
Pashazadeh, Rahim
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Jul2012, Vol. 53 Issue 27, p3440-3443. 4p.
Publication Year :: 2012
Abstract: Abstract: l-Proline efficiently catalyzes the one-pot, three-component reaction of homophthalic anhydride, amines, and aldehydes in CH3CN at room temperature, to afford the corresponding cis-isoquinolonic acids in high yields and with excellent diastereoselectivities. The synthesized compounds are screened for neuroprotective activities. [Copyright &y& Elsevier]

Subjects :: *ASYMMETRIC synthesis
*PROLINE
*NEUROPROTECTIVE agents
*QUINOLONE antibacterial agents
*CATALYSTS
*ACETONITRILE
*ANHYDRIDES
*TEMPERATURE effect

Language :: English
ISSN :: 00404039
Volume :: 53
Issue :: 27
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 76351790
Full Text :: https://doi.org/10.1016/j.tetlet.2012.04.089

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