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Triggering of drug release of particles in hair follicles

Authors :
Mak, Wing Cheung
Patzelt, Alexa
Richter, Heike
Renneberg, Reinhardt
Lai, Kwok Kei
Rühl, Eckart
Sterry, Wolfram
Lademann, Jürgen
Source :
Journal of Controlled Release. Jun2012, Vol. 160 Issue 3, p509-514. 6p.
Publication Year :
2012

Abstract

Abstract: Particulate drug delivery via hair follicles represents a promising concept, although requirements are high. This process must be realized at the desired depth and at the appropriate time, due to the fact that the particles themselves are not able to overcome the follicular skin barrier. In the present study, a novel triggering concept for the release of a model drug from the delivering particles is presented based on the application of two different particle types of the same size, where one particle type is the drug carrier, and the second one is loaded with a protease. The latter particle type is supposed to interact with the drug-carrying particles to trigger the drug release. A mixture of both particles was applied onto porcine skin samples, followed by follicular analysis. As a control, the particles were applied unaided without protease, whereas one skin area remained untreated. The investigations revealed that the protease was able to release the model drug from the delivering particles in significant depths within the hair follicle (866±62nm). Additionally, an uptake of the model drug in the sebaceous gland was observed after release providing a promising novel approach for the development of treatment strategies for different skin diseases. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
01683659
Volume :
160
Issue :
3
Database :
Academic Search Index
Journal :
Journal of Controlled Release
Publication Type :
Academic Journal
Accession number :
76465357
Full Text :
https://doi.org/10.1016/j.jconrel.2012.04.007