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CTLA-4 blockade synergizes with cryoablation to mediate tumor rejection.

Authors :
Waitz, Rebecca
Fassò, Marcella
Allison, James P.
Source :
OncoImmunology. Jul2012, Vol. 1 Issue 4, p544-546. 3p.
Publication Year :
2012

Abstract

We report that cryoablation of primary tumors synergizes with anti-CTLA-4 treatment to mediate rejection of secondary tumors in the TRAMP mouse model of prostate cancer. T cells, in particular CD8+ T cells specific for the TRAMP antigen SPAS-1, were enriched in both secondary tumors and spleens of combination-treated mice. [ABSTRACT FROM AUTHOR]

Subjects

Subjects :
*LABORATORY mice
*CD8 antigen
*T cells
*PROSTATE cancer
*MONOCLONAL antibodies
*TUMOR immunology

Details

Language :
English
ISSN :
21624011
Volume :
1
Issue :
4
Database :
Academic Search Index
Journal :
OncoImmunology
Publication Type :
Academic Journal
Accession number :
76531538
Full Text :
https://doi.org/10.4161/onci.19442
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