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Perifosine sensitizes UVB-induced apoptosis in skin cells: New implication of skin cancer prevention?
- Source :
-
Cellular Signalling . Sep2012, Vol. 24 Issue 9, p1781-1789. 9p. - Publication Year :
- 2012
-
Abstract
- Abstract: We demonstrate here that a relative low dose of perifosine significantly enhanced UVB-induced apoptosis in skin cells (keratinocytes and fibroblasts), associated with a significant increase of reactive oxygen species (ROS) and ceramide production as well as multiple perturbations of diverse cell signaling pathways, shifting to a significant pro-apoptosis outcomes. Perifosine inhibited UVB-induced pro-survival Akt/mammalian target of rapamycin (mTOR) and ERK activation, while facilitating pro-apoptotic AMP-activated protein kinas (AMPK), c-Jun-NH2-kinase (JNK), and p53 activation; these signaling changes together promoted a striking increase in skin cell apoptosis and a significantly reduced amount of DNA damages. Our results suggest that perifosine may represent a novel skin cancer prevention strategy. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 08986568
- Volume :
- 24
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Cellular Signalling
- Publication Type :
- Academic Journal
- Accession number :
- 77289099
- Full Text :
- https://doi.org/10.1016/j.cellsig.2012.05.003