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The role of hepatitis B virus-specific memory CD8 T cells in the control of viral replication
- Source :
-
Journal of Hepatology . Jan2002, Vol. 36 Issue 1, p105. 11p. - Publication Year :
- 2002
-
Abstract
- Background/Aims: The aim of this study is to clarify the differences of host immune responses between acute self-limited and chronic persistent hepatitis B virus (HBV) infections by quantitative and qualitative analysis of HLA-A*2402-restricted HBV-specific CD8+ T cells.Methods: HBV-specific CD8+ T cells in peripheral blood mononuclear cells (PBMCs) from patients infected with HBV were analyzed by flow cytometry using two HLA-A*2402–HBV peptide tetrameric complexes.Results: High numbers of HBV-specific CD8+ T cells were detected in acute phase PBMCs from most individuals with acute HBV infection while the number of these cells was greatly reduced in recovery phase PBMCs. HBV-specific CD8+ T cells were not detected in PBMCs from individuals with chronic HBV infection except for one patient during acute exacerbation. HBV-specific CD8+ T cells were induced by in vitro peptide stimulation in PBMCs from chronic HBV carriers with a low level of serum HBV-DNA but not from those with a high level of serum HBV-DNA. CD28CD45RA phenotype analysis showed that HBV-specific CD8+ T cells in acute phase PBMCs predominantly express a memory T cell phenotype.Conclusions: HBV-specific memory CD8+ T cells may play a crucial role in complete clearance of HBV from patients with acute HBV hepatitis. [Copyright &y& Elsevier]
- Subjects :
- *TETRAMERS (Oligomers)
*T cells
*HEPATITIS B virus
Subjects
Details
- Language :
- English
- ISSN :
- 01688278
- Volume :
- 36
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Hepatology
- Publication Type :
- Academic Journal
- Accession number :
- 7743615
- Full Text :
- https://doi.org/10.1016/S0168-8278(01)00264-1