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Cytotoxic T Lymphocyte Antigen-4 Accumulation in the Immunological Synapse Is Regulated by TCR Signal Strength
- Source :
-
Immunity (10747613) . Jan2002, Vol. 16 Issue 1, p23. 13p. - Publication Year :
- 2002
-
Abstract
- CD28 and CTLA-4 engagement with B7 expressed by APCs generates critical regulatory signals for T cell activation. CD28 is expressed on the T cell surface and enhances T cell expansion, while CTLA-4 localizes primarily to an intracellular compartment and inhibits T cell proliferation. We demonstrate that CTLA-4 has several unique trafficking properties that may regulate its ability to attenuate a T cell response. Importantly, accumulation of CTLA-4 at the immunological synapse is proportional to the strength of the TCR signal, suggesting that cells receiving stronger stimuli are more susceptible to CTLA-4-mediated inhibition. This may represent a novel feedback control mechanism in which a stimulatory signal regulates the recruitment of an inhibitory receptor to a functionally relevant site on the cell surface. [Copyright &y& Elsevier]
- Subjects :
- *T cells
*CELL proliferation
Subjects
Details
- Language :
- English
- ISSN :
- 10747613
- Volume :
- 16
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Immunity (10747613)
- Publication Type :
- Academic Journal
- Accession number :
- 7749669
- Full Text :
- https://doi.org/10.1016/S1074-7613(01)00259-X