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<atl>A Combinatorial Library of Indinavir Analogues and Its In Vitro and In Vivo Studies
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Feb2002, Vol. 12 Issue 4, p529. 4p. - Publication Year :
- 2002
-
Abstract
- A combinatorial library of 300HIV protease inhibitors has been synthesized. The library was screened against recombinant wild-type and mutant HIV-1 protease enzymes. The pharmacokinetics of the library was evaluated by dosing in dogs. Compounds that are notably more potent than indinavir and have favorable pharmacokinetic properties were identified. [Copyright &y& Elsevier]
- Subjects :
- *PROTEOLYTIC enzymes
*GENE libraries
*PHARMACOKINETICS
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 12
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 7752829
- Full Text :
- https://doi.org/10.1016/S0960-894X(01)00824-1